In this study, we present a deep learning framework that learns complex spatio-temporal correlation structures of EEG signals through a Spatio-Temporal Attention Network (ST AN) for accurate predictions of onset of seizures for Epilepsy patients. Unlike existing methods, which rely on feature engineering and/or assume fixed preictal durations, our approach simultaneously models spatio-temporal correlations through ST AN and employs an adversarial discriminator to distinguish preictal from interictal attention patterns, enabling patient-specific learning. Evaluation on CHB-MIT and MSSM datasets demonstrates 96.6% sensitivity with 0.011/h false detection rate on CHB-MIT, and 94.2% sensitivity with 0.063/h FDR on MSSM, significantly outperforming state-of-the-art methods.

As the field of healthcare increasingly adopts artificial intelligence, it becomes important to understand which types of explanations increase transparency and empower users to develop confidence and trust in the predictions made by machine learning (ML) systems. In shared decision-making scenarios where doctors cooperate with ML systems to reach an appropriate decision, establishing mutual trust is crucial. In this paper, we explore different approaches to generating explanations in eXplainable AI (XAI) and make their underlying arguments explicit so that they can be evaluated by medical experts. In particular, we present the findings of a user study conducted with physicians to investigate their perceptions of various types of AI-generated explanations in the context of diagnostic decision support. The study aims to identify the most effective and useful explanations that enhance the diagnostic process. In the study, medical doctors filled out a survey to assess different types of explanations. Further, an interview was carried out post-survey to gain qualitative insights on the requirements of explanations incorporated in diagnostic decision support. Overall, the insights gained from this study contribute to understanding the types of explanations that are most effective.

Early-warning signals of delicate design are always used to predict critical transitions in complex systems, which makes it possible to render the systems far away from the catastrophic state by introducing timely interventions. Traditional signals including the dynamical network biomarker (DNB), based on statistical properties such as variance and autocorrelation of nodal dynamics, overlook directional interactions and thus have limitations in capturing underlying mechanisms and simultaneously sustaining robustness against noise perturbations. This paper therefore introduces a framework of causal network markers (CNMs) by incorporating causality indicators, which reflect the directional influence between variables. Actually, to detect and identify the tipping points ahead of critical transition, two markers are designed: CNM-GC for linear causality and CNM-TE for non-linear causality, as well as a functional representation of different causality indicators and a clustering technique to verify the system's dominant group. Through demonstrations using benchmark models and real-world datasets of epileptic seizure, the framework of CNMs shows higher predictive power and accuracy than the traditional DNB indicator. It is believed that, due to the versatility and scalability, the CNMs are suitable for comprehensively evaluating the systems. The most possible direction for application includes the identification of tipping points in clinical disease.

Multi-channel EEG signals are commonly used for the diagnosis and assessment of diseases such as epilepsy. Currently, various EEG diagnostic algorithms based on deep learning have been developed. However, most research efforts focus solely on diagnosing and classifying current signal data but do not consider the prediction of future trends for early warning. Additionally, since multi-channel EEG can be essentially regarded as the spatio-temporal signal data received by detectors at different locations in the brain, how to construct spatio-temporal information representations of EEG signals to facilitate future trend prediction for multi-channel EEG becomes an important problem. This study proposes a multi-signal prediction algorithm based on generative diffusion models (EEG-DIF), which transforms the multi-signal forecasting task into an image completion task, allowing for comprehensive representation and learning of the spatio-temporal correlations and future developmental patterns of multi-channel EEG signals. Here, we employ a publicly available epilepsy EEG dataset to construct and validate the EEG-DIF. The results demonstrate that our method can accurately predict future trends for multi-channel EEG signals simultaneously. Furthermore, the early warning accuracy for epilepsy seizures based on the generated EEG data reaches 0.89. In general, EEG-DIF provides a novel approach for characterizing multi-channel EEG signals and an innovative early warning algorithm for epilepsy seizures, aiding in optimizing and enhancing the clinical diagnosis process. The code is available at https://github.com/JZK00/EEG-DIF.

Analyzing electroencephalogram (EEG) signals to detect the epileptic seizure status of a subject presents a challenge to existing technologies aimed at providing timely and efficient diagnosis. In this study, we aimed to detect interictal and ictal periods of epileptic seizures using a spiking neural network (SNN). Our proposed approach provides an online and real-time preliminary diagnosis of epileptic seizures and helps to detect possible pathological conditions.To validate our approach, we conducted experiments using multiple datasets. We utilized a trained SNN to identify the presence of epileptic seizures and compared our results with those of related studies. The SNN model was deployed on Xylo, a digital SNN neuromorphic processor designed to process temporal signals. Xylo efficiently simulates spiking leaky integrate-and-fire neurons with exponential input synapses. Xylo has much lower energy requirments than traditional approaches to signal processing, making it an ideal platform for developing low-power seizure detection systems.Our proposed method has a high test accuracy of 93.3% and 92.9% when classifying ictal and interictal periods. At the same time, the application has an average power consumption of 87.4 uW(IO power) + 287.9 uW(computational power) when deployed to Xylo. Our method demonstrates excellent low-latency performance when tested on multiple datasets. Our work provides a new solution for seizure detection, and it is expected to be widely used in portable and wearable devices in the future.

Epilepsy affects more than 50 million people worldwide, making it one of the world's most prevalent neurological diseases. The main symptom of epilepsy is seizures, which occur abruptly and can cause serious injury or death. The ability to predict the occurrence of an epileptic seizure could alleviate many risks and stresses people with epilepsy face. We formulate the problem of detecting preictal (or pre-seizure) with reference to normal EEG as a precursor to incoming seizure. To this end, we developed several supervised deep learning approaches to identify preictal EEG from normal EEG. We further develop novel unsupervised deep learning approaches to train the models on only normal EEG, and detecting pre-seizure EEG as an anomalous event. These deep learning models were trained and evaluated on two large EEG seizure datasets in a person-specific manner. We found that both supervised and unsupervised approaches are feasible; however, their performance varies depending on the patient, approach and architecture. This new line of research has the potential to develop therapeutic interventions and save human lives.

Early warning for epilepsy patients is crucial for their safety and well-being, in particular to prevent or minimize the severity of seizures. Through the patients' EEG data, we propose a meta learning framework to improve the prediction of early ictal signals. The proposed bi-level optimization framework can help automatically label noisy data at the early ictal stage, as well as optimize the training accuracy of the backbone model. To validate our approach, we conduct a series of experiments to predict seizure onset in various long-term windows, with LSTM and ResNet implemented as the baseline models. Our study demonstrates that not only the ictal prediction accuracy obtained by meta learning is significantly improved, but also the resulting model captures some intrinsic patterns of the noisy data that a single backbone model could not learn. As a result, the predicted probability generated by the meta network serves as a highly effective early warning indicator.

Detecting early warning indicators for abrupt dynamical transitions in complex systems or high-dimensional observation data is essential in many real-world applications, such as brain diseases, natural disasters, financial crises, and engineering reliability. To this end, we develop a novel approach: the directed anisotropic diffusion map that captures the latent evolutionary dynamics in the low-dimensional manifold. Then three effective warning signals (Onsager-Machlup Indicator, Sample Entropy Indicator, and Transition Probability Indicator) are derived through the latent coordinates and the latent stochastic dynamical systems. To validate our framework, we apply this methodology to authentic electroencephalogram (EEG) data. We find that our early warning indicators are capable of detecting the tipping point during state transition. This framework not only bridges the latent dynamics with real-world data but also shows the potential ability for automatic labeling on complex high-dimensional time series.

In this work, we contribute towards the development of video-based epileptic seizure classification by introducing a novel framework (SETR-PKD), which could achieve privacy-preserved early detection of seizures in videos. Specifically, our framework has two significant components - (1) It is built upon optical flow features extracted from the video of a seizure, which encodes the seizure motion semiotics while preserving the privacy of the patient; (2) It utilizes a transformer based progressive knowledge distillation, where the knowledge is gradually distilled from networks trained on a longer portion of video samples to the ones which will operate on shorter portions. Thus, our proposed framework addresses the limitations of the current approaches which compromise the privacy of the patients by directly operating on the RGB video of a seizure as well as impede real-time detection of a seizure by utilizing the full video sample to make a prediction. Our SETR-PKD framework could detect tonic-clonic seizures (TCSs) in a privacy-preserving manner with an accuracy of 83.9% while they are only half-way into their progression. Our data and code is available at https://github.com/DevD1092/seizure-detection

Epilepsy is a prevalent neurological disorder characterized by recurrent and unpredictable seizures, necessitating accurate prediction for effective management and patient care. Application of machine learning (ML) on electroencephalogram (EEG) recordings, along with its ability to provide valuable insights into brain activity during seizures, is able to make accurate and robust seizure prediction an indispensable component in relevant studies. In this research, we present a comprehensive comparative analysis of five machine learning models - Random Forest (RF), Decision Tree (DT), Extra Trees (ET), Logistic Regression (LR), and Gradient Boosting (GB) - for the prediction of epileptic seizures using EEG data. The dataset underwent meticulous preprocessing, including cleaning, normalization, outlier handling, and oversampling, ensuring data quality and facilitating accurate model training. These preprocessing techniques played a crucial role in enhancing the models' performance. The results of our analysis demonstrate the performance of each model in terms of accuracy. The LR classifier achieved an accuracy of 56.95%, while GB and DT both attained 97.17% accuracy. RT achieved a higher accuracy of 98.99%, while the ET model exhibited the best performance with an accuracy of 99.29%. Our findings reveal that the ET model outperformed not only the other models in the comparative analysis but also surpassed the state-of-the-art results from previous research. The superior performance of the ET model makes it a compelling choice for accurate and robust epileptic seizure prediction using EEG data.